Article

Disentangling Pontine Fiber Geometry and Microstructure in ARSACS Using Advanced MRI

2026-05-28

Abstract excerpt

1 <h4>Background</h4> Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a genetic disease characterized by spasticity and ataxia which reflects involvement of the corticospinal tracts (CST) and cerebellum. The primary involvement of the middle cerebellar peduncles (MCP) and transverse pontine fibers (TPF) at the crossing with the CST, and their role in the pathophysiology of the disease, is cu...

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Literature Corpus work: ac0ea3c9-a282-59aa-a8e3-d85342c7124d
DOI: 10.64898/2026.05.20.26353196

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