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Article

Donor-derived acute myeloid leukemia in solid organ transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 1 Dec 2022

Marchionni Luigi, Lobo Francisco Pereira, Kostadinov Rumen, Serra Anna, Besso Federico Genzano, Deaglio Silvia, Stratta Piero, Berrino Monica, Zanettini Claudio, Imada Eddie Luidy, Omar Mohamed N, Gaidano Gianluca, Bruno Benedetto, Saglio Giuseppe, Amoroso Antonio

Abstract excerpt

We report the transmission of acute myeloid leukemia (AML) undetected at donation from a deceased organ donor to two kidneys and one liver recipients. We reviewed the medical records, and performed molecular analyses and whole exome sequencing (WES) to ascertain AML donor origin and its molecular evolution. The liver recipient was diagnosed 11 months after transplantation and died from complications 2 months...

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Identifiers

PMID: 35979657
DOI: 10.1111/ajt.17174
PMCID: PMC9897593

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