Back to search

Article

Age-specific Reference Intervals for Serum GFAP and UCH-L1 in Children and Adolescents

2026-06-16

Abstract excerpt

<h4>Background: </h4> Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) are promising blood biomarkers for reducing unnecessary CT imaging in children with mild traumatic brain injury (mTBI). However, paediatric reference intervals (RIs) and age-related variation in biomarker concentrations remains poorly defined. This study aimed to establish paediatric RIs for GFAP and UCH-L1...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
abbf6cf6-4476-526e-b0f2-c9f81fb542f3
DOI
10.3310/nihropenres.14246.1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Age-specific Reference Intervals for Serum GFAP and UCH-L1 in Children and AdolescentsDOI 10.3310/nihropenres.14246.1
The game changer: UCH-L1 and GFAP-based blood test as the first marketed in vitro diagnostic test for mild traumatic brain injurySemantic proximity
Age-specific control and Alzheimer’s disease reference curves and z-scores for glial fibrillary acidic protein in bloodSemantic proximity
Blood-Based CNS-Injury and Inflammation Biomarkers Sampled at Acute, Subacute, and Chronic phases After Mild TBI Demonstrate Diagnostic Utility For Patients With and Without Intracranial Injuries on Acute CT and MRISemantic proximity
Clinical and neuroimaging phenotypes of autoimmune glial fibrillary acidic protein astrocytopathy: A systematic review and meta-analysis.Semantic proximity
Global, regional, and national burdens of traumatic brain injury in adolescents and young adults aged 10-24 years from 1990 to 2021: A secondary analysis of the Global Burden of Disease Study 2021Semantic proximity
Variation in Candidate Traumatic Brain Injury Biomarker Genes Are Associated with Gross Neurological Outcomes after Severe Traumatic Brain Injury.Semantic proximity
Challenges and Opportunities for Neuroimaging in Young Patients with Traumatic Brain Injury: a Coordinated Effort towards Advancing Discovery from the ENIGMA Pediatric Moderate/Severe TBI GroupSemantic proximity
Development, External Validation, and Biomolecular Corroboration of Interoperable Models for Identifying Critically Ill Children at Risk of Neurologic MorbiditySemantic proximity
GFAP Degradation in TBI: Linking Novel Modified Products to Astrocyte Pathology and Patient OutcomeSemantic proximity
Budget Impact Analysis of the Use of Specific Biomarkers GFAP and UCH-L1 in the Management of Mild Traumatic Brain Injury in SpainSemantic proximity
Plasma Biomarker Profile and Clinical Correlations in Adult Patients With Tuberous Sclerosis Complex.Semantic proximity
Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease.Semantic proximity
Select a neighboring publication to make it the new centre.