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HPV16/18 Genotyping Combined with PAX1 Methylation Triage Reduces Unnecessary Colposcopy While Improving CIN3+ Detection: A Real-World Study of 3,253 Chinese Women

2025-12-18

Abstract excerpt

<h4>Background: </h4> : Current cervical cancer screening guidelines recommend colposcopy referral for women co-positive for high-risk human papillomavirus (hrHPV) and abnormal cytology (≥ASC-US). However, cytology exhibits suboptimal sensitivity, and this strategy leads to high colposcopy burdens, especially in populations where non-HPV16/18 genotypes predominate. We evaluated a novel triage strategy using HPV16/...

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Literature Corpus work
ab515b13-93cb-5878-98b4-cac843ef21ed
DOI
10.22541/au.176603959.96579141/v1
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HPV16/18 Genotyping Combined with PAX1 Methylation Triage Reduces Unnecessary Colposcopy While Improving CIN3+ Detection: A Real-World Study of 3,253 Chinese WomenDOI 10.22541/au.176603959.96579141/v1
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