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Article

PAX1 methylation for triage of HR-HPV-positive women: a comparative analysis with cytology and HPV16/18 genotyping.

BMC cancer - 25 May 2026

Tong Zhengjiao, Mao Saiping, Tao Hong, Gan Peng, Li Hongtao, Pei Xiaozhu, Fan Xing

Abstract excerpt

OBJECTIVE: To evaluate PAX1 hypermethylation (PAX1m) as a triage strategy test for cervical intraepithelial neoplasia grade 3 or worse (CIN3+) in high-risk human papillomavirus (HR-HPV)-positive women versus liquid-based cytology (LBC) and HPV16/18 genotyping. METHODS: This prospective, diagnostic accuracy study enrolled 1,461 h-HPV-positive women. All underwent colposcopy and biopsy. Triage strategies (PAX1m,...

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Identifiers

PMID: 42178528
DOI: 10.1186/s12885-026-16235-4
PMCID: PMC13386616

Genes

PAX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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