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Article

Melanoma-derived extracellular vesicles skew neutrophils into a pro-tumor phenotype.

Journal of leukocyte biology - 1 Mar 2022

Guimarães-Bastos Daniel, Frony Ana Clara, Barja-Fidalgo Christina, Moraes João Alfredo

Abstract excerpt

Evidence shows that tumor cells abundantly produce and release extracellular vesicles (EVs) that can interact with stromal cells and modulate their functions. In the tumor neighborhood, neutrophils can assume both antitumor and pro-tumor phenotypes, known as TAN-N1 and TAN-N2, respectively. Nevertheless, the contribution of tumor-derived EVs to the modulation of TAN phenotypes is still poorly understood. The...

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PMID: 34043843
DOI: 10.1002/JLB.3A0120-050RR

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