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Article

TRIM47 is a prognostic biomarker for gallbladder cancer and promotes tumor progression through regulating K63-linked ubiquitination of PARP1

2 Nov 2024

Abstract excerpt

• TRIM47 expression was significantly elevated in GBC tissues and associated with poor prognosis. • TRIM47 promotes GBC development by mediating K63-linked polyubiquitination of PARP1, which stabilizes its expression and activates the AKT signaling pathway. • TRIM47 plays a crucial role in regulating PARP1 polyubiquitination, and it is a powerful biomarker that is useful for predicting the prognosis of GBC and an...

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Cancer Mechanisms and Therapy
Cytokine Signaling Pathways and Interactions
interferon and immune responses

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39489093
DOI: 10.1016/j.tranon.2024.102164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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