Article

LRRK2 kinase inhibition protects against Parkinson’s disease-associated environmental toxicants

2024-03-31

Abstract excerpt

Idiopathic Parkinson’s disease (PD) is epidemiologically linked with exposure to toxicants such as pesticides and solvents, which comprise a wide array of chemicals that pollute our environment. While most are structurally distinct, a common cellular target for their toxicity is mitochondrial dysfunction, a key pathological trigger involved in the selective vulnerability of dopaminergic neurons. We and others have...

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Literature Corpus work: aab7b622-7a48-5051-995e-322529b22c44
DOI: 10.1101/2024.03.29.587369

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