Back to search

Article

Exposure to the organochlorine pesticide cis-chlordane induces ALS-like mitochondrial perturbations in stem cell-derived motor neurons

2025-06-08

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a debilitating and incurable neurodegenerative disease with unsolved etiology. Due to the large proportion of patients lacking direct disease inheritance, understanding the environmental factors that contribute to ALS development is of high priority. Epidemiological studies have implicated pesticides and other environmental exposures as possible contributors to ALS pathogenes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
671f0fdb-b004-5522-ba41-4783d73b4951
DOI
10.1101/2025.06.05.658119
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Exposure to the organochlorine pesticide cis-chlordane induces ALS-like mitochondrial perturbations in stem cell-derived motor neuronsDOI 10.1101/2025.06.05.658119
Single cell analysis of gene expression in the substantia nigra pars compacta of a pesticide-induced mouse model of Parkinson’s diseaseSemantic proximity
Single-cell analysis of gene expression in the substantia nigra pars compacta of a pesticide-induced mouse model of Parkinson’s diseaseSemantic proximity
Coupling comprehensive pesticide-wide association study to iPSC dopaminergic screening identifies and classifies Parkinson-relevant pesticidesSemantic proximity
Transcriptome Analysis of a Rotenone Model of Parkinsonism Reveals Complex I-Tied and -Untied Toxicity Mechanisms Common to Neurodegenerative DiseasesSemantic proximity
How is Excitotoxicity Being Modelled in iPSC-Derived Neurons?Semantic proximity
LRRK2 kinase inhibition protects against Parkinson’s disease-associated environmental toxicantsSemantic proximity
Elucidating Conserved Transcriptional Networks Underlying Pesticide Exposure and Parkinson's Disease: A Focus on Chemicals of Epidemiological RelevanceSemantic proximity
A LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysisSemantic proximity
Exposure to a mixture of BMAA and MCLR synergistically modulates behavior in larval zebrafish while exacerbating molecular changes related to neurodegenerationSemantic proximity
Editor's Highlight: Embryonic Exposure to the Environmental Neurotoxin BMAA Negatively Impacts Early Neuronal Development and Progression of Neurodegeneration in the Sod1-G93R Zebrafish Model of Amyotrophic Lateral Sclerosis.Semantic proximity
Evaluation of cyanotoxin L-BMAA effect on α-synuclein and TDP43 proteinopathySemantic proximity
High-Content Screening Identifies Dithiocarbamates As A Class Of Chemicals That Disrupts TDP-43 ProteostasisSemantic proximity
Select a neighboring publication to make it the new centre.