Article

Predicting hERG repolarization power at 37°C from recordings at room temperature

2023-04-14

Abstract excerpt

Mutations in the KCNH2 gene cause long or short QT syndromes (LQTS or SQTS) predisposing to life-threatening arrhythmias. KCNH2 encodes for the voltage-gated K + channel hERG involved in the late repolarization phase of the cardiac action potential (AP). For the last decades, sequencing KCNH2 has provided a plethora of variants associated or not with clear pathological cardiac phenotypes. Identifying pathogeni...

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Literature Corpus work: aa258a86-f030-5137-9aaa-74f0e2930f41
DOI: 10.1101/2023.04.13.536707

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