Article

Oxygen concentration modulates colibactin production

2022-06-20

Abstract excerpt

Up to 25% of the E. coli strains isolated from the feces of healthy humans harbor the pks genomic island encoding the synthesis of colibactin, a genotoxic metabolite. Evidence is accumulating for an etiologic role of colibactin in colorectal cancer. Little is known about the conditions of expression of colibactin in the gut. The intestine is characterized by a unique oxygenation profile, with a steep gradient be...

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Literature Corpus work: a9f3baf8-a763-5253-b432-f8677d3b3498
DOI: 10.1101/2022.06.20.496773

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