Article

HSP90 buffers deleterious genetic variations in <i>BRCA1</i>

2024-11-17

Abstract excerpt

<h4>SUMMARY</h4> Protein-folding chaperone HSP90 buffers genetic variation in diverse organisms, but the clinical significance of HSP90 buffering in disease remains unclear. Here, we show that HSP90 buffers mutations in the BRCT domain of BRCA1. HSP90-buffered BRCA1 mutations encode protein variants that retain interactions with partner proteins and rely on HSP90 for protein stability and function in cell surviv...

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Literature Corpus work: a9e1ee01-6977-5e30-9a1e-ac820c47988f
DOI: 10.1101/2024.11.15.623783

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