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Article

HSP90 buffers deleterious genetic variations in BRCA1.

Molecular cell - 4 Dec 2025

Gracia Brant, Zhang Xing-Han, Montes Patricia, Pham Tin Chanh, Huang Min, Chen Junjie, Karras Georgios Ioannis

Abstract excerpt

Protein-folding chaperone heat shock protein 90 (HSP90) buffers genetic variation in diverse organisms, but the clinical significance of HSP90 buffering in human disease remains unclear. Here, we show that HSP90 buffers mutations in the BRCT domain of BRCA1. HSP90-buffered BRCA1 mutations result in protein variants that retain interactions with partner proteins and strongly rely on HSP90 for protein stability and...

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Topics

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Share to BRCA1 Protein
Share to Breast Neoplasms
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to HSP90 Heat-Shock Proteins

Share to Mutation, Missense

Share to Poly(ADP-ribose) Polymerase Inhibitors

Share to Protein Stability

Source

Open in PubMed Open full text

Identifiers

PMID: 41265458
DOI: 10.1016/j.molcel.2025.10.026
PMCID: PMC12648472

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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