Article

Protein-Folding Chaperones Predict Structure-Function Relationships and Cancer Risk in <i>BRCA1</i> Mutation Carriers

2023-09-15

Abstract excerpt

<h4>ABSTRACT</h4> Identifying pathogenic mutations and predicting their impact on protein structure, function and phenotype remain major challenges in genome sciences. Protein-folding chaperones participate in structure-function relationships by facilitating the folding of protein variants encoded by mutant genes. Here, we utilize a high-throughput protein-protein interaction assay to test HSP70 and HSP90 chapero...

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Literature Corpus work: adb1edaf-4ceb-5299-8800-e87c354c335f
DOI: 10.1101/2023.09.14.557795

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