Article
Amelogenesis imperfecta and other biomineralization defects in Fam20a and Fam20c null mice.
Veterinary pathology - 1 Nov 2012
Vogel P, Hansen G M, Read R W, Vance R B, Thiel M, Liu J, Wronski T J, Smith D D, Jeter-Jones S, Brommage R
Abstract excerpt
The FAM20 family of secreted proteins consists of three members (FAM20A, FAM20B, and FAM20C) recently linked to developmental disorders suggesting roles for FAM20 proteins in modulating biomineralization processes. The authors report here findings in knockout mice having null mutations affecting each of the three FAM20 proteins. Both Fam20a and Fam20c null mice survived to adulthood and showed biomineralization...
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