Article

Hypoxia induces cytotoxicity and suppresses cytokine production by CD8□ T cells in cutaneous leishmaniasis

2026-08-04

Abstract excerpt

Cutaneous leishmaniasis is characterized by chronic inflammatory skin lesions in which CD8□ T cells exhibit paradoxical functions. While IFN-γ-producing CD8□ T cells contribute to the development of protective immunity in the draining lymph node, CD8□ T cells recruited to the infected skin lose their ability to produce IFN-γ and instead acquire cytotoxic functions that exacerbate tissue damage. We previously demon...

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Literature Corpus work: a9cae8bb-7a8c-5d07-95da-0bc89b25cc18
DOI: 10.64898/2026.07.30.741849

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