Article

Reaction of nitrocefin with two serines of Pseudomonas aeruginosa penicillin-binding-protein 3

2022-06-17

Abstract excerpt

<title>Abstract</title> <p>Despite their clinical importance, the mechanisms by which β-lactams inhibit penicillin-binding-proteins (PBPs) are not fully defined. X-ray crystallographic and mass spectrometric data studies of a Pseudomonas aeruginosa PBP3 active site variant (Tyr409Ala) reveal evidence for the <italic>in vitro</italic> acylation of P. aeruginosa PBP3 by reaction of nitrocefin with both Ser294 and S...

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Literature Corpus work: a9479d36-59cd-5098-b8b9-8fa1d910d135
DOI: 10.21203/rs.3.rs-1727322/v1

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