Article

Dissecting the contribution of common variants to risk of rare neurodevelopmental conditions

2024-03-06

Abstract excerpt

Although rare neurodevelopmental conditions have a large Mendelian component, common genetic variants also contribute to risk. However, little is known about how this polygenic risk is distributed among patients with these conditions and their parents, its interplay with rare variants, and whether parents’ polygenic background contributes to their children’s risk beyond the direct effect of variants transmitted to...

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Literature Corpus work: a8db691b-7239-53f7-b881-5ddcdae15793
DOI: 10.1101/2024.03.05.24303772

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