Article

Identifying high-priority proteins across the human diseasome using semantic similarity

2018-04-29

Abstract excerpt

Knowledge of “popular proteins” has been a focus of multiple Human Proteome Organization (HUPO) initiatives and can guide the development of proteomics assays targeting important disease pathways. We report here an updated method to identify prioritized protein lists from the research literature, and apply it to catalog lists of important proteins across multiple cell types, sub-anatomical regions, and disease phe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a8896f02-c8c4-5cbf-801e-390ced959c65
DOI: 10.1101/309203

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identifying high-priority proteins across the human diseasome using semantic similarityDOI 10.1101/309203Read

A reliable and unbiased human protein network with the disparity filterSemantic proximity Read

Human symptoms-disease network.Semantic proximity Read

Progress Identifying and Analyzing the Human Proteome: 2021 Metrics from the HUPO Human Proteome ProjectSemantic proximity Read

HPOSim: an R package for phenotypic similarity measure and enrichment analysis based on the human phenotype ontology.Semantic proximity Read

Exploring the cellular basis of human disease through a large-scale mapping of deleterious genes to cell types.Semantic proximity Read

Accelerating the search for the missing proteins in the human proteomeSemantic proximity Read

Prioritization of orphan disease-causing genes using topological feature and GO similarity between proteins in interaction networks.Semantic proximity Read

Biomechanisms of Comorbidity: Reviewing Integrative Analyses of Multi-omics Datasets and Electronic Health Records.Semantic proximity Read

Synteny – a high throughput web tool to streamline causal gene prioritisation and provide insight into protein functionSemantic proximity Read

A scored human protein-protein interaction network to catalyze genomic interpretationSemantic proximity Read

Synteny - a high throughput web tool to streamline causal gene prioritisation and provide insight into protein function.Semantic proximity Read

Phen2Disease: a phenotype-driven model for disease and gene prioritization by bidirectional maximum matching semantic similarities.Semantic proximity Read