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Synteny - a high throughput web tool to streamline causal gene prioritisation and provide insight into protein function.

Scientific reports - 29 Dec 2025

Cutler Harry B, Stöckli Jacqueline, Madsen Søren, Masson Stewart W C, Fuller Oliver K, Shum Tom Buckingham, James David E

Abstract excerpt

Accounting for human genetic evidence can improve the outcomes and impact of basic medical research studies. However, current approaches are incompatible with the high volume of disease-associated genes that require mechanistic interrogation and risk overlooking important phenotypic associations. Synteny responds to an urgent need in systems biology, scaling human genetic analysis to match the throughput of...

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PMID: 41462053
DOI: 10.1038/s41598-025-28473-w
PMCID: PMC12749926

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