Article

<i>APOE4</i> genotype and <i>MAPT</i> haplotype modify repetitive head impact biomarkers in retired professional fighters

2025-09-21

Abstract excerpt

Long-term vulnerability to brain injury after repetitive head impacts (RHI) is poorly predicted in vivo. The wide heterogeneity of outcomes suggests that common genetic variants may act as modifiers of RHI-related neurodegeneration. Here, we tested whether APOE ε4 and MAPT H1/H2 haplotypes function as genetic modifiers of biomarker trajectories in 111 retired professional fighters from the Professional Athletes Br...

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Literature Corpus work: a8877f94-8012-595a-9bf3-e7a894f41cdd
DOI: 10.1101/2025.09.19.25335803

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<i>APOE4</i> genotype and <i>MAPT</i> haplotype modify repetitive head impact biomarkers in retired professional fightersDOI 10.1101/2025.09.19.25335803Read

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