Back to search

Article

In Silico Research of New Therapeutics Rotenoids Derivatives Against Leishmania Amazonensis Infection

2021-12-16

Abstract excerpt

Yearly, 1,500,000 cases of leishmaniasis are diagnosed, causing thousands of deaths. To advance in its therapy, we present an interdisciplinary protocol that unifies ethnobotanical knowledge of natural compounds and the latest bioinformatics advances to respond to an orphan disease such as leishmaniasis and specifically the one caused by Leishmania amazonensis. The use of ethnobotanical information serves as a bas...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a7efee44-80aa-5292-acc4-91576b6eaa35
DOI
10.20944/preprints202112.0276.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
In Silico Research of New Therapeutics Rotenoids Derivatives Against Leishmania Amazonensis InfectionDOI 10.20944/preprints202112.0276.v1
Computer-aided drug design approaches applied to screen natural product’s structural analogs targeting arginase in Leishmania sppSemantic proximity
16α‐Hydroxycleroda‐3,13 (14)Z‐dien‐15,16‐olide from Polyalthia longifolia: a safe and orally active antileishmanial agentSemantic proximity
Phytochemicals as potential drug candidates for targeting SARS CoV 2 proteins, an in silico studySemantic proximity
Targeting with Structural Analogs of Natural Products the Purine Salvage Pathway in Leishmania (Leishmania) infantum by Computer-Aided Drug-Design ApproachesSemantic proximity
Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infectionsSemantic proximity
In silico and in vitro comparative activity of novel experimental derivatives against Leishmania major and Leishmania infantum promastigotesSemantic proximity
In-silico screening for anti-Zika virus phytochemicalsSemantic proximity
Network-Based Approaches Reveal Potential Therapeutic Targets for Host-Directed Antileishmanial Therapy Driving Drug RepurposingSemantic proximity
DRUG DISCOVERY AND DEVELOPMENT FOR NEGLECTED TROPICAL DISEASESSemantic proximity
Molecular scaffold recognition of drug molecules against essential genes of Leishmania donovani using biocomputing approachSemantic proximity
Drug screening and development cascade for Chagas disease: an update of in vitro and in vivo experimental models.Semantic proximity
Repurposing of the Open Access Malaria Box for Kinetoplastid Diseases Identifies Novel Active Scaffolds against TrypanosomatidsSemantic proximity
Select a neighboring publication to make it the new centre.