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Article

Inhibitor of DNA binding 2 is a novel therapeutic target for stemness of head and neck squamous cell carcinoma.

British journal of cancer - 5 Dec 2017

Bae Woo Jin, Koo Bon Seok, Lee Sang Hyuk, Kim Jin Man, Rho Young Soo, Lim Jae Yol, Moon Jung Hwa, Cho Jae Hoon, Lim Young Chang

Abstract excerpt

BACKGROUND: Head and neck squamous cell carcinomas (HNSCCs) are highly lethal epithelial tumours containing self-renewal cancer stem cells (CSCs). CSCs in HNSCCs are strongly associated with tumour initiation, invasion, and chemoradiation resistance. However, the important factors regulating stemness in HNSCCs remain unclear. Here, we investigated the molecular roles and clinical significance of inhibitor of DNA...

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Identifiers

PMID: 29096401
DOI: 10.1038/bjc.2017.373
PMCID: PMC5729481

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