Article

SARS-CoV-2 Triggers Complement Activation through Interactions with Heparan Sulfate

2022-01-11

Abstract excerpt

<h4>ABSTRACT</h4> The complement system has been heavily implicated in severe COVID-19 with clinical studies revealing widespread gene induction, deposition, and activation. However, the mechanism by which complement is activated in this disease remains incompletely understood. Herein we examined the relationship between SARS-CoV-2 and complement by inoculating the virus in lepirudin-anticoagulated human blood. T...

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Literature Corpus work: a777c5d1-9d15-5bd9-b98a-87454defae01
DOI: 10.1101/2022.01.11.475820

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