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Improved <i>de novo</i> Genome Assembly: Linked-Read Sequencing Combined with Optical Mapping Produce a High Quality Mammalian Genome at Relatively Low Cost

2017-04-18

Abstract excerpt

Current short-read methods have come to dominate genome sequencing because they are cost-effective, rapid, and accurate. However, short reads are most applicable when data can be aligned to a known reference. Two new methods for de novo assembly are linked-reads and restriction-site labeled optical maps. We combined commercial applications of these technologies for genome assembly of an endangered mammal, the Haw...

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Literature Corpus work
a6f97b19-34a3-5cc0-9e8b-e39703a96b72
DOI
10.1101/128348
Open publication

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Improved <i>de novo</i> Genome Assembly: Linked-Read Sequencing Combined with Optical Mapping Produce a High Quality Mammalian Genome at Relatively Low CostDOI 10.1101/128348
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