Back to search

Article

Innovative In Vitro-In Silico Platform for Dose-Response Modeling in Canine Bladder Cancer: A 3D Organoid- and Mathematics-Based Approach

2025-09-17

Abstract excerpt

<title>Abstract</title> <p>Approximately 25% of human urothelial carcinoma (UC) cases progress to high-grade, muscle-invasive bladder cancer (MIBC), for which treatment response remains difficult to predict. To address the need for more predictive platforms, we developed an integrated <italic>in vitro</italic>–<italic>in silico</italic> system using canine UC derived organoids, which closely mirror human MIBC at...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a5a20410-710b-57ff-b53b-a13ac2801c89
DOI
10.21203/rs.3.rs-7614200/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Innovative In Vitro-In Silico Platform for Dose-Response Modeling in Canine Bladder Cancer: A 3D Organoid- and Mathematics-Based ApproachDOI 10.21203/rs.3.rs-7614200/v1
FOLLOW-U; study protocol evaluating oncological systemic treatment response of advanced bladder cancer patients using urinoidsSemantic proximity
Integrated molecular and pharmacological characterization of patient-derived xenografts from bladder and ureteral cancers identifies new potential therapiesSemantic proximity
Leveraging a Patient-Derived Tumoroid Platform for Precision Radiotherapy: Uncovering DNA Damage Repair Inhibitor-Mediated Radiosensitization and Therapeutic Resistance in Rectal CancerSemantic proximity
Assessing Radiosensitivity of Bladder Cancer in vitro: A 2D vs. 3D ApproachSemantic proximity
Guidance of adjuvant instillation in intermediate risk non- muscle invasive bladder cancer by drug screens in patient derived organoids. A Single center, Open-label, Phase II trial. GAIN-INST-TrialSemantic proximity
Integrative Drug Screening and Multiomic Characterization of Patient-derived Bladder Cancer Organoids Reveal Novel Molecular Correlates of Gemcitabine ResponseSemantic proximity
An integrative ex vivo platform for mapping therapy-induced cellular adaptations in urothelial carcinoma: GLUT1 as an example of chemotherapy-induced metabolic resistanceSemantic proximity
Towards personalized computational oncology: from spatial models of tumour spheroids, to organoids, to tissuesSemantic proximity
Establishment of an experimental model of normal dog bladder organoid using a three-dimensional culture methodSemantic proximity
Cell Viability or Image-based Analysis: Evaluation of Dose Response of Patient-derived Cancer Organoids to IrradiationSemantic proximity
Cell Viability or Image-based Analysis: Evaluation of Dose Response of Patient- derived Cancer Organoids to Irradiation Running Title: Dose Response of Cancer Organoids to IrradiationSemantic proximity
Ex vivo modelling of drug efficacy in a rare metastatic urachal carcinoma.Semantic proximity
Select a neighboring publication to make it the new centre.