Article
The effects of age, sex, weight, and breed on canid methylomes.
Epigenetics - 1 Nov 2022
Rubbi Liudmilla, Zhang Haoxuan, Feng Junxi, He Christopher, Kurnia Patrick, Ratan Prashansa, Tammana Aakash, House Sabina, Thompson Michael, Farrell Colin, Snir Sagi, Stahler Daniel, Ostrander Elaine A, vonHoldt Bridgett M, Pellegrini Matteo
Abstract excerpt
Unlike genomes, which are static throughout the lifespan of an organism, DNA methylomes are dynamic. To study these dynamics, we developed quantitative models that measure the effect of multiple factors on DNA methylomes including, age, sex, weight, and genetics. We conducted our study in canids, which prove to be an ideal species to assess epigenetic moderators due to their extreme variability in size and...
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