Article

A Computational approach to uncover the missense mutations in candidate genes of late-onset Alzheimer’s disease

2022-09-20

Abstract excerpt

<title>Abstract</title> <p>Background Alzheimer’s (induced by ultimate demise of nerve cells) is a neurodegenerative disorder, and experts are still lagging in this disease, owing to the polygenic and multi-factorial nature mainly in Late-Onset-Alzheimer’s-Disease (LOAD). Till now, Amyloid beta (Aβ) aggregation along with neuroinflammation seem to be the main inveterate attribute of Alzheimer’s Disease (AD). Hen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a4c0cba5-b73d-5a80-94a1-637892cfec3c
DOI: 10.21203/rs.3.rs-2060964/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Computational approach to uncover the missense mutations in candidate genes of late-onset Alzheimer’s diseaseDOI 10.21203/rs.3.rs-2060964/v1Read

Analysis of Alzheimer's disease associated deleterious non-synonymous single nucleotide polymorphisms and their impacts on protein structure and function by performing in-silico methods.Semantic proximity Read

Genetic Study of Alzheimer’s Disease in Saudi PopulationSemantic proximity Read

Computational analysis and molecular dynamics simulation of high-risk single nucleotide polymorphisms of the ADAM10 gene.Semantic proximity Read

Exploration of deleterious single nucleotide polymorphisms in late-onset Alzheimer disease susceptibility genes.Semantic proximity Read

Computational Screening and Exploration of Disease-Associated Genes in Alzheimer's Disease.Semantic proximity Read

Computational prediction of high-risk non-synonymous SNPs in human ApoE and their structural impact on amyloid-β interaction in Alzheimer’s disease pathogenesisSemantic proximity Read

Evaluation of the Clinical Features Accompanied by the Gene Mutations: The 2 Novel PSEN1 Variants in a Turkish Early-onset Alzheimer Disease Cohort.Semantic proximity Read

Alz-Disc: A Tool to Discriminate Disease-causing and Neutral Mutations in Alzheimer's Disease.Semantic proximity Read

Novel PSEN1 G209A mutation in early-onset Alzheimer dementia supported by structural prediction.Semantic proximity Read

Alzheimer's Disease: The Role of Mutations in Protein Folding.Semantic proximity Read

Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants.Semantic proximity Read

Predictive Analysis of Brain-Derived Neurotrophic Factor and Apolipoprotein E SNPs in Alzheimer’s PathogenesisSemantic proximity Read