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Alzheimer's Disease: The Role of Mutations in Protein Folding.

Advances in experimental medicine and biology - 1 Jan 2020

Polychronidou Eleftheria, Avramouli Antigoni, Vlamos Panayiotis

Abstract excerpt

Misfolded proteins result when a protein follows the wrong folding pathway. Accumulation of misfolded proteins can cause disorders, known as amyloid diseases. Unfortunately, some of them are very common. The most prevalent one is Alzheimer's disease. Alzheimer's disease is a neurodegenerative disorder and the commonest form of dementia. The current study aims to assess the impact of somatic mutations in PSEN1...

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PMID: 32468481
DOI: 10.1007/978-3-030-32633-3_31

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