Article

Compensated Structural Savantism: Neurogenomic Characterization of High Cognitive Ability in a Phenotype at Risk for Autism Spectrum Disorder

2026-02-06

Abstract excerpt

This case study (N=1) investigates the neurobiological and genomic architecture of a male individual with a history of exceptional cognitive performance (profound giftedness), contrasted with behavioral traits of neurodivergence. Integrated analysis of polygenic risk scores (PRS), structural neuroimaging, and cognitive assessment reveals a rare phenotype termed here as "Compensated Structural Savantism". The resul...

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Literature Corpus work: a4b135cc-22ab-5911-b800-f29f4be113cf
DOI: 10.20944/preprints202602.0529.v1

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