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Host DNA depletion assisted metagenomic sequencing of bronchoalveolar lavage fluids for diagnosis of pulmonary tuberculosis

2024-02-20

Abstract excerpt

<title>Abstract</title> <p>[Background]Metagenomic next-generation sequencing (mNGS) has greatly improved our understanding of pathogens in infectious diseases such as pulmonary tuberculosis (PTB). However, high human DNA background (> 95%) impedes the detection sensitivity of mNGS in identifying intracellular <italic>Mycobacterium tuberculosis</italic> (MTB), posing a pressing challenge for MTB diagnosis. Theref...

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Literature Corpus work
8b86a056-f3d8-553c-890a-1dc0fddc3cf3
DOI
10.21203/rs.3.rs-3870666/v1
Open publication

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Host DNA depletion assisted metagenomic sequencing of bronchoalveolar lavage fluids for diagnosis of pulmonary tuberculosisDOI 10.21203/rs.3.rs-3870666/v1
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