Article

De novo design of functionally diverse and druggable antimicrobial peptides by diffusion and multimodal deep learning

2025-07-19

Abstract excerpt

The escalating crisis of antibiotic resistance underscores the urgent need for innovative anti-infective agents, such as antimicrobial peptides (AMPs), though their discovery and optimization remain challenging. To address this, we introduce AMP-D3, a comprehensive framework that integrates AMP generation, identification, and screening into a cohesive workflow. Central to AMP-D3 is PACD, an advanced generator that...

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Identifiers and source

Literature Corpus work: 7faec581-eb32-5980-9150-de5fb3222c1c
DOI: 10.1101/2025.07.16.665042

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