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Article

Predicting the functional impact of single nucleotide variants in Drosophila melanogaster with FlyCADD.

Genetics - 7 Jan 2026

Beets Julia, Höglund Julia, Kim Bernard Y, Ellers Jacintha, Hoedjes Katja M, Bosse Mirte

Abstract excerpt

Understanding how genetic variants drive phenotypic differences is a major challenge in molecular biology. Single nucleotide polymorphisms form the vast majority of genetic variation and play critical roles in complex, polygenic phenotypes, yet their functional impact is poorly understood from traditional gene-level analyses. In-depth knowledge about the impact of single nucleotide polymorphisms has broad...

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PMID: 41270030
DOI: 10.1093/genetics/iyaf250
PMCID: PMC12774831

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GC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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