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Article

Prioritizing sequence variants in conserved non-coding elements in the chicken genome using chCADD.

PLoS genetics - 1 Sept 2020

Groß Christian, Bortoluzzi Chiara, de Ridder Dick, Megens Hendrik-Jan, Groenen Martien A M, Reinders Marcel, Bosse Mirte

Abstract excerpt

The availability of genomes for many species has advanced our understanding of the non-protein-coding fraction of the genome. Comparative genomics has proven itself to be an invaluable approach for the systematic, genome-wide identification of conserved non-protein-coding elements (CNEs). However, for many non-mammalian model species, including chicken, our capability to interpret the functional importance of...

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PMID: 32966296
DOI: 10.1371/journal.pgen.1009027
PMCID: PMC7535126

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