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Article

Meta-analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape.

Epilepsia - 1 Mar 2026

Durante Giovanna L, Tyler Anna L, Scott Rod C, Hernan Amanda E, Mahoney J Matthew

Abstract excerpt

OBJECTIVE: Despite decades of development in anti-seizure medications, ~30% of individuals remain refractory to all treatments, and none of the existing therapies are disease modifying. Identifying targets outside the current preclinical paradigm is critically important. This study aimed to characterize the landscape of current epilepsy treatments at the level of gene interaction networks and identify novel...

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Identifiers

PMID: 41358547
DOI: 10.1111/epi.70035
PMCID: PMC13007847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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