Article

Cell-type specific global reprogramming of the transcriptome and epigenome in induced neurons with the 16p11.2 neuropsychiatric CNVs

2023-08-04

Abstract excerpt

<title>Abstract</title>Copy number variants (CNVs), either deletions or duplications, at the 16p11.2 locus in the human genome are known to increase the risk for autism spectrum disorders (ASD), schizophrenia, and several other developmental conditions. Here, we investigate the global effects on gene expression and DNA methylation using a 16p11.2 CNV patient-derived induced pluripotent stem cell (iPSC) to induc...

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Literature Corpus work: a30ff181-1a09-5d11-b67c-3a8c72bf3ec1
DOI: 10.21203/rs.3.rs-3152672/v1

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