Article

Short-term exposure to culture media used in human ART shapes early calcium oscillations in ICSI-fertilized mouse oocytes and impacts adult phenotype

2025-03-16

Abstract excerpt

<h4>Purpose</h4> The influence of culture media used during in vitro fertilization (IVF) on offspring phenotype remains controversial. However, specific effects of short exposure time after fertilization remain underexplored. By evaluating Ca 2+ oscillations as a readout of the first response of eggs to their microenvironment, we aim to investigate if early differences correlate with later adult phenotypes. <h4...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a2f4967d-9001-5c8b-a94c-158ad52d85e6
DOI: 10.1101/2025.03.14.643329

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Short-term exposure to culture media used in human ART shapes early calcium oscillations in ICSI-fertilized mouse oocytes and impacts adult phenotypeDOI 10.1101/2025.03.14.643329Read

[Mg2+]o/[Ca2+]o determines Ca2+ response at fertilization: tuning of adult phenotype?Semantic proximity Read

PMCA1 depletion in mouse eggs amplifies calcium signaling and impacts offspring growthSemantic proximity Read

Multiparameter assessment of mouse oogenesis during follicular growth in vitroSemantic proximity Read

Oocyte cryopreservation and in vitro culture affect calcium signalling during human fertilizationSemantic proximity Read

The <i>in vitro</i> growth and maturation of folliclesSemantic proximity Read

CaV3.2 T-type channels mediate Ca2+ entry during oocyte maturation and following fertilizationSemantic proximity Read

The duration of embryo culture after mouse IVF differentially affects cardiovascular and metabolic health in male offspringSemantic proximity Read

Effects of embryo culture media do not persist after implantation: a histological study in miceSemantic proximity Read

Comparative study of preimplantation development following distinct assisted oocyte activation protocols in a PLC-zeta knockout mouse modelSemantic proximity Read

ICSI-generated mouse zygotes exhibit altered calcium oscillations, inositol 1,4,5-trisphosphate receptor-1 down-regulation, and embryo developmentSemantic proximity Read

Ionomycin-induced mouse oocyte activation can disrupt preimplantation embryo development through increased reactive oxygen species reaction and DNA damageSemantic proximity Read

In Vitro Fertilization Affects Growth and Glucose Metabolism in a Sex-Specific Manner in an Outbred Mouse Model1Semantic proximity Read