Article

Attenuated replication and damaging effects of SARS-CoV-2 Omicron variants in an intestinal epithelial barrier model

2024-02-28

Abstract excerpt

<h4>ABSTRACT</h4> Many COVID-19 patients suffer from gastrointestinal symptoms and impaired intestinal barrier function may play a key role in Long COVID. Despite its importance, the impact of SARS-CoV-2 on intestinal epithelia is poorly understood. To address this, we established an intestinal barrier model integrating epithelial Caco-2 cells, mucus-secreting HT29 cells and human Raji cells. This gut epithelial...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a2a0976e-b8be-5aa4-a97a-c172c01a0d58
DOI: 10.1101/2024.02.28.582510

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Attenuated replication and damaging effects of SARS-CoV-2 Omicron variants in an intestinal epithelial barrier modelDOI 10.1101/2024.02.28.582510Read

SARS-CoV-2 Omicron BA.1 variant infection of human colon epithelial cellsSemantic proximity Read

SARS-CoV-2 Omicron BA.2.86 & JN.1 shifting tropism from airway to intestineSemantic proximity Read

SARS-CoV-2 Omicron subvariants progressively adapt to human cells with altered host cell entrySemantic proximity Read

BA.1, BA.2 and BA.2.75 variants show comparable replication kinetics, reduced impact on epithelial barrier and elicit cross-neutralizing antibodiesSemantic proximity Read

Why Does SARS-CoV-2 Invade the Gastrointestinal Epithelium?Semantic proximity Read

Variable susceptibility of intestinal organoid-derived monolayers to SARS-CoV-2 infectionSemantic proximity Read

SARS-CoV-2 Productively Infects Human Gut EnterocytesSemantic proximity Read

Differential Cell Line Susceptibility to the SARS-CoV-2 Omicron BA.1.1 Variant of ConcernSemantic proximity Read

Dissection of barrier dysfunction in organoid-derived human intestinal epithelia induced by <i>Giardia duodenalis</i>Semantic proximity Read

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVsSemantic proximity Read

SARS-CoV-2 Omicron variant is attenuated for replication in a polarized human lung epithelial cell modelSemantic proximity Read

Berbamine suppresses intestinal SARS-CoV-2 infection via a BNIP3-dependent autophagy blockadeSemantic proximity Read