Article

TLNRD1 is a CCM complex component and regulates endothelial barrier integrity

2023-09-29

Abstract excerpt

We previously identified talin rod domain-containing protein 1 (TLNRD1) as a potent actin-bundling protein in vitro. Here, we report that TLNRD1 is primarily expressed in the vasculature in vivo and that its depletion leads to vascular abnormalities in vivo and loss of barrier integrity in cultured endothelial cells. We demonstrate that TLNRD1 is a component of the cerebral cavernous malformations (CCM) complex th...

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Literature Corpus work: a2976578-71cf-5bee-bd47-831b987f2fab
DOI: 10.1101/2023.09.29.559344

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