Article

The integration site of the APP transgene in the J20 mouse model of Alzheimer’s disease

2018-10-10

Abstract excerpt

<h4>Background: </h4> Transgenic animal models are a widely used and powerful tool to investigate human disease and develop therapeutic interventions. Making a transgenic mouse involves random integration of exogenous DNA into the host genome that can have the effect of disrupting endogenous gene expression. The J20 mouse model of Alzheimer’s disease (AD) is a transgenic overexpresser of human APP with familial AD...

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Literature Corpus work: a294ff94-83cd-521f-bd2b-bc2da76583ff
DOI: 10.12688/wellcomeopenres.12237.2

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