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Article

Transgene integration causes RARB downregulation in homozygous Tg4-42 mice.

Scientific reports - 14 Apr 2020

Hinteregger Barbara, Loeffler Tina, Flunkert Stefanie, Neddens Joerg, Birner-Gruenberger Ruth, Bayer Thomas A, Madl Tobias, Hutter-Paier Birgit

Abstract excerpt

Alzheimer's disease can be modelled by different transgenic mouse strains. To gain deeper insight into disease model mechanisms, the previously described Tg4-42 mouse was analysed for transgene integration. On RNA/DNA level the transgene integration resulted in more than 20 copy numbers and further caused a deletion of exon 2 of the retinoic acid receptor beta. These findings were also confirmed on protein level...

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Source

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Identifiers

PMID: 32286473
DOI: 10.1038/s41598-020-63512-8
PMCID: PMC7156671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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