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Article

M-DATA: A statistical approach to jointly analyzing de novo mutations for multiple traits.

PLoS genetics - 1 Nov 2021

Xie Yuhan, Li Mo, Dong Weilai, Jiang Wei, Zhao Hongyu

Abstract excerpt

Recent studies have demonstrated that multiple early-onset diseases have shared risk genes, based on findings from de novo mutations (DNMs). Therefore, we may leverage information from one trait to improve statistical power to identify genes for another trait. However, there are few methods that can jointly analyze DNMs from multiple traits. In this study, we develop a framework called M-DATA (Multi-trait...

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Identifiers

PMID: 34735430
DOI: 10.1371/journal.pgen.1009849
PMCID: PMC8568192

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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