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Article

mTADA is a framework for identifying risk genes from de novo mutations in multiple traits.

Nature communications - 10 Jun 2020

Nguyen Tan-Hoang, Dobbyn Amanda, Brown Ruth C, Riley Brien P, Buxbaum Joseph D, Pinto Dalila, Purcell Shaun M, Sullivan Patrick F, He Xin, Stahl Eli A

Abstract excerpt

Joint analysis of multiple traits can result in the identification of associations not found through the analysis of each trait in isolation. Studies of neuropsychiatric disorders and congenital heart disease (CHD) which use de novo mutations (DNMs) from parent-offspring trios have reported multiple putatively causal genes. However, a joint analysis method designed to integrate DNMs from multiple studies has yet...

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PMID: 32522981
DOI: 10.1038/s41467-020-16487-z
PMCID: PMC7287090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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