Article

Bestrophin-4 relays HES4 and interacts with TWIST1 to suppress epithelial-to-mesenchymal transition in colorectal cancer cells

2024-12-19

Abstract excerpt

Bestrophin isoform 4 ( BEST4 ) is a newly identified subtype of the calcium-activated chloride channel family. Analysis of colonic epithelial cell diversity by single-cell RNA-sequencing has revealed the existence of a cluster of BEST4 + mature colonocytes in humans. However, if the role of BEST4 is involved in regulating tumour progression remains largely unknown. In this study, we demonstrate that BEST4 overexpr...

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Literature Corpus work: a24116ee-5717-5f33-bded-a0c93b15befe
DOI: 10.7554/elife.88879.3

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