Article

Therapeutic vulnerability to PARP1,2 inhibition in RB1-mutant osteosarcoma

2021-02-05

Abstract excerpt

<title>Abstract</title> <p>Loss-of-function mutations in the <italic>RB1</italic> tumour suppressor are key drivers in cancer, including osteosarcoma. <italic>RB1</italic> loss-of-function compromises genome-maintenance and hence could yield vulnerability to therapeutics targeting such processes. Here we demonstrate selective hypersensitivity to clinically-approved inhibitors of Poly-ADP-Polymerase1,2 inhibitors...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a1ebd2d0-26e5-5736-94c8-3d4e9b7dbefa
DOI: 10.21203/rs.3.rs-185226/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Therapeutic vulnerability to PARP1,2 inhibition in RB1-mutant osteosarcomaDOI 10.21203/rs.3.rs-185226/v1Read

Therapeutic vulnerability to PARP1,2 inhibition in RB1-mutant osteosarcomaSemantic proximity Read

Therapeutic vulnerability to PARP1/2 inhibition in <i>RB1</i> -mutant osteosarcomaSemantic proximity Read

Strategies for the prevention or reversal of PARP inhibitor resistance.Semantic proximity Read

‘Where is my gap’: mechanisms underpinning PARP inhibitor sensitivity in cancerSemantic proximity Read

Resistance to PARP Inhibitors: Lessons from Preclinical Models of BRCA-Associated CancerSemantic proximity Read

Osteosarcoma cells with genetic signatures of BRCAness are susceptible to the PARP inhibitor talazoparib alone or in combination with chemotherapeuticsSemantic proximity Read

PARP1 roles in DNA repair and DNA replication: The basi(c)s of PARP inhibitor efficacy and resistanceSemantic proximity Read

Clinical approaches to overcome PARP inhibitor resistanceSemantic proximity Read

Potential agnostic role of BRCA alterations in patients with several solid tumors: One for all, all for one?Semantic proximity Read

PARP Inhibitors: Extending Benefit Beyond BRCA -Mutant CancersSemantic proximity Read

PARPi, BRCA, and gaps: controversies and future researchSemantic proximity Read

Insights into the Possible Molecular Mechanisms of Resistance to PARP InhibitorsSemantic proximity Read