Behavioral phenotyping identifies autism-like repetitive stereotypies in a Tsc2 haploinsufficient rat model

Abstract excerpt

<title>Abstract</title> <p>Besides deficits in social communication and interaction, repetitive behavior patterns are core manifestations of autism spectrum disorder (ASD). Phenotypes are heterogeneous and can range from simple lower-order motor stereotypies to more complex higher-order cognitive inflexibility and fixated interests. Due to ASD’s multifaceted etiology, animal models are often generated from monoge...

Topics

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• Autism Spectrum Disorder
• Cognition
• Germ-Line Mutation
• Heterozygote
• Intelligence Tests
• Megalencephaly
• PTEN Phosphohydrolase
• Stereotyped Behavior

Identifiers and source

Literature Corpus work

a15adcd9-9329-50f9-a506-41910cabb883

DOI

10.21203/rs.3.rs-6006061/v1