Article

mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticus

2021-02-12

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Tuberous Sclerosis Complex (TSC), a multi-system genetic disorder often associated with Autism Spectrum Disorder (ASD), is caused by mutations of <italic>TSC1</italic> or <italic>TSC2</italic>,<italic> </italic>which lead to constitutive overactivation of mammalian Target of Rapamycin (mTOR). In several <italic>Tsc1+/-</italic> and <italic>Tsc2+/-</italic> anima...

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Literature Corpus work: 654f5607-d477-5cbb-a65b-56f8900493ce
DOI: 10.21203/rs.3.rs-122455/v2

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