Article

The gut microbiota is a determinant of sexual dimorphism in ALS-linked TDP43 mice

2024-08-30

Abstract excerpt

The mechanisms underlying the earlier onset and male predominance of amyotrophic lateral sclerosis (ALS), the most common form of human motoneuron disease, are poorly understood. Here we show that the gut microbiota protects against TDP43 toxicity and contributes to the sexual dimorphism in mice expressing a mutant form of TDP43 (A315T) linked to ALS. TDP43 mice raised under germ-free conditions, or treated with a...

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Literature Corpus work: a14d5f03-0f18-55e7-8b12-5fe7bb90a5cb
DOI: 10.1101/2024.08.29.610355

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