Article

Postnatal depression-associated breastmilk extracellular vesicles mediate intergenerational effects on offspring neurodevelopment

2026-04-21

Abstract excerpt

<title>Abstract</title> <p>Postnatal depression (PND) increases the risk of neurodevelopmental impairments in offspring, yet the underlying mechanisms remain elusive. Here, we identify an intergenerational signaling pathway whereby maternal psychological state is encoded in breastmilk microRNAs (miRNAs) and transmitted to offspring via breastmilk small extracellular vesicles (sEVs). Using cross-fostering models,...

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Literature Corpus work: a103425b-1ce0-5a9e-9376-51939c4bfa06
DOI: 10.21203/rs.3.rs-9365315/v1

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