Article

Neurochemical phenotype of relaxin family peptide receptor-3 (RXFP3) lateral hypothalamus/zona incerta cells

2026-04-12

Abstract excerpt

The relaxin-3/relaxin family peptide receptor 3 (RXFP3) neuropeptidergic system is emerging as a potential target for treating various neuropsychiatric diseases, particularly those involving dysregulated stress and arousal. RXFP3 is abundantly expressed in several hypothalamic nuclei, and in the zona incerta (ZI). These regions play a central role in the regulation of stress and arousal, however the function of re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a0418fa8-c59f-52ec-ab3b-008ba826571a
DOI: 10.64898/2026.04.09.717598

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neurochemical phenotype of relaxin family peptide receptor-3 (RXFP3) lateral hypothalamus/zona incerta cellsDOI 10.64898/2026.04.09.717598Read

Restricted, but abundant, expression of the novel rat gene‐3 (R3) relaxin in the dorsal tegmental region of brainSemantic proximity Read

Identification of Relaxin-3/INSL7 as an Endogenous Ligand for the Orphan G-protein-coupled Receptor GPCR135Semantic proximity Read

Probing the functional domains of relaxin-3 and the creation of a selective antagonist for RXFP3/GPCR135 over relaxin receptor RXFP1/LGR7.Semantic proximity Read

RFamide-Related Peptide Neurons Modulate Reproductive Function and Stress Responses.Semantic proximity Read

Development, sex steroid regulation, and phenotypic characterization of RFamide-related peptide (Rfrp) gene expression and RFamide receptors in the mouse hypothalamus.Semantic proximity Read

Chronic variable mild stress alters the transcriptome and signaling properties of the anterodorsal bed nuceleus of the stria terminalis in a sex-dependent mannerSemantic proximity Read

Comparative transcriptomics of lateral hypothalamic cell types reveals conserved growth hormone-tachykinin dynamics in feedingSemantic proximity Read

A subset of dorsal raphe dopamine neurons is critical for survival-oriented vigilanceSemantic proximity Read

Role of posterodorsal medial amygdala urocortin-3 in pubertal timing in female miceSemantic proximity Read

Characterization of corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus of Crh-IRES-Cre mutant mice.Semantic proximity Read

Dual phenotype kisspeptin-dopamine neurones of the rostral periventricular area of the third ventricle project to gonadotrophin-releasing hormone neurones.Semantic proximity Read

Early Development of the Gonadotropin-Releasing Hormone Neuronal Network in Transgenic ZebrafishSemantic proximity Read